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pentobarbital will decrease the extent or impact of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Outcome of coadministering a solid CYP3A4 inducer with fedratinib hasn't been researched.pentobarbital and olopatadine intranasal the two enhance sedation. Prevent or Use Alternate Drug. Coad